Neuromyelitis optica: association with paroxysmal painful tonic spasms. / Neuromielitis óptica: asociación con espasmos tónicos paroxísticos dolorosos.
Neurologia
; 31(8): 511-5, 2016 Oct.
Article
em En, Es
| MEDLINE
| ID: mdl-25655945
ABSTRACT
INTRODUCTION:
Paroxysmal painful tonic spasms (PPTS) were initially described in multiple sclerosis (MS) but they are more frequent in neuromyelitis optica (NMO). The objective is to report their presence in a series of cases of NMO and NMO spectrum disorders (NMOSD), as well as to determine their frequency and clinical features. PATIENTS ANDMETHODS:
We conducted a retrospective assessment of medical histories of NMO/NMOSD patients treated in 2 hospitals in Buenos Aires (Hospital Durand and Hospital Álvarez) between 2009 and 2013.RESULTS:
Out of 15 patients with NMOSD (7 with definite NMO and 8 with limited NMO), 4 presented PPTS (26.66%). PPTS frequency in the definite NMO group was 57.14% (4/7). Of the 9 patients with longitudinally extensive transverse myelitis (LETM), 44.44% (9/15) presented PPTS. Mean age was 35 years (range, 22-38 years) and all patients were women. Mean time between NMO diagnosis and PPTS onset was 7 months (range, 1-29 months) and mean time from last relapse of LETM was 30 days (range 23-40 days). LETM (75% cervicothoracic and 25% thoracic) was observed by magnetic resonance imaging (MRI) in all patients. Control over spasms and pain was achieved in all patients with carbamazepine (associated with gabapentin in one case). No favourable responses to pregabalin, gabapentin, or phenytoin were reported.CONCLUSIONS:
PPTS are frequent in NMO. Mean time of PPTS onset is approximately one month after an LETM relapse, with extensive cervicothoracic lesions appearing on the MRI scan. They show an excellent response to carbamazepine but little or no response to pregabalin and gabapentin. Prospective studies with larger numbers of patients are necessary in order to confirm these results.Palavras-chave
Esclerosis múltiple; Espasmos tónicos paroxísticos dolorosos; Espectro de la neuromielitis óptica; Longitudinally extensive transverse myelitis; Mielitis transversa longitudinal extensa; Multiple sclerosis; Neuromielitis óptica; Neuromyelitis optica; Neuromyelitis optica spectrum disorders; Paroxysmal painful tonic spasms
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Espasmo
/
Neuromielite Óptica
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
/
Es
Ano de publicação:
2016
Tipo de documento:
Article