A strategy for measuring the therapeutic properties of new antiparkinsonian drugs, such as +PHNO, in patients with on-off fluctuations.

Coleman, R J; Temlett, J A; Quinn, N P; Stahl, S M; Marsden, C D

Coleman, R J; Temlett, J A; Quinn, N P; Stahl, S M; Marsden, C D.

Afiliação

Coleman RJ; Institute of Psychiatry, London, U.K.

Clin Neuropharmacol ; 12(1): 37-45, 1989 Feb.

Article em En | MEDLINE | ID: mdl-2565765

RESUMO

We describe a simple quantitative bedside method for assessing the dopaminergic properties of new therapeutic agents, namely, by documenting their duration of action in patients with Parkinson's disease who exhibit "on-off" fluctuations. This model represents a form of human dopaminergic "bioassay".

Assuntos

Antiparkinsonianos/farmacologia; Dopaminérgicos/farmacologia; Oxazinas/farmacologia; Doença de Parkinson/tratamento farmacológico; Adulto; Idoso; Avaliação de Medicamentos/métodos; Feminino; Humanos; Masculino; Pessoa de Meia-Idade

Buscar no Google

Imprimir

XML

PubMed Links

Base de dados: MEDLINE Assunto principal: Oxazinas / Doença de Parkinson / Dopaminérgicos / Antiparkinsonianos Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1989 Tipo de documento: Article

Buscar no Google

Imprimir

XML

PubMed Links