Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin.
Int J Exp Pathol
; 96(2): 73-80, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25664478
ABSTRACT
Transplantable murine melanomas are well-established models for the study of experimental cancer therapies. The aim of this study was to explore the behaviour of four different B16 murine melanoma cell sublines after inoculation into C57BL/6J mice; and, more specifically to analyse skin changes, with respect to two specific parameters clinical (tumour volume, melanin amount, erythema) and histological (H & E, S100, VEGF expression). Both non-invasive and invasive analysis showed that B164A5 is the most aggressive melanoma cell line for C57BL/6J's skin, followed by B16F10 and then by diminished aggressive growth pattern by the B16GMCSF and B16FLT3 cell lines.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
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Neoplasias Cutâneas
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Transplante de Células
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Linhagem Celular Tumoral
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Melanoma
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article