[Immune system and psychiatric disorders: involvement of BDNF and intracellular Ca2+ signaling].
Seishin Shinkeigaku Zasshi
; 116(10): 832-41, 2014.
Article
em Ja
| MEDLINE
| ID: mdl-25672210
ABSTRACT
Nonresolving low-grade inflammation is supposed to underly the basis of chronic disorders including cancer, type 2 diabetes, cardiovascular diseases, obesity and psychiatric disorders such as depression. There is increasing evidence suggesting that pathophysiology of psychiatric disorders is related to the inflammatory responses mediated by microglial cells. Elevation of intracellular Ca2+ is important in activation of microglial cell functions, including proliferation, release of NO, cytokines and BDNF. It has been shown that alteration of intracellular Ca2+ signaling underlies the pathophysiology of psychiatric disorders, including schizophrenia, depression and bipolar disorders. Microglial cells are able to respond to BDNF, which may be important for the regulation of inflammatory responses, and may also be involved in the pathophysiology and/or the treatment of psychiatric disorders.
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Base de dados:
MEDLINE
Assunto principal:
Fator Neurotrófico Derivado do Encéfalo
/
Sinalização do Cálcio
/
Sistema Imunitário
/
Transtornos Mentais
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Ja
Ano de publicação:
2014
Tipo de documento:
Article