Genetic studies of body mass index yield new insights for obesity biology.
Nature
; 518(7538): 197-206, 2015 Feb 12.
Article
em En
| MEDLINE
| ID: mdl-25673413
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for â¼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Índice de Massa Corporal
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Estudo de Associação Genômica Ampla
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Obesidade
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Female
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Humans
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Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article