Suppression of discoidin domain receptor 1 expression enhances the chondrogenesis of adipose-derived stem cells.

Wu, Shun-Cheng; Hsiao, Hsu-Feng; Ho, Mei-Ling; Hung, Yung-Li; Chang, Je-Ken; Wang, Gwo-Jaw; Wang, Chau-Zen

Wu, Shun-Cheng; Hsiao, Hsu-Feng; Ho, Mei-Ling; Hung, Yung-Li; Chang, Je-Ken; Wang, Gwo-Jaw; Wang, Chau-Zen.

Afiliação

Wu SC; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hsiao HF; Department of Family Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan;
Ho ML; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
Hung YL; Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
Chang JK; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiun
Wang GJ; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Orthopedic Surgery, University of Virginia, Charlottesville, Virginia; Medical Device Innovation Center, National Cheng-Kung University, Tainan, Taiwan; and Skeleton-Joint Research Center
Wang CZ; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; czw

Am J Physiol Cell Physiol ; 308(9): C685-96, 2015 May 01.

Article em En | MEDLINE | ID: mdl-25673773

Assuntos

Condrócitos/metabolismo; Condrogênese; Receptores Proteína Tirosina Quinases/metabolismo; Células-Tronco/metabolismo; Gordura Subcutânea/metabolismo; Agrecanas/genética; Agrecanas/metabolismo; Diferenciação Celular; Sobrevivência Celular; Células Cultivadas; Colágeno Tipo II/genética; Colágeno Tipo II/metabolismo; Subunidade alfa 1 de Fator de Ligação ao Core/genética; Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo; Receptor com Domínio Discoidina 1; Regulação da Expressão Gênica; Glicosaminoglicanos/metabolismo; Humanos; Metaloproteinase 13 da Matriz/genética; Metaloproteinase 13 da Matriz/metabolismo; Fenótipo; Interferência de RNA; RNA Mensageiro/metabolismo; Receptores Proteína Tirosina Quinases/genética; Fatores de Transcrição SOX9/genética; Fatores de Transcrição SOX9/metabolismo; Transdução de Sinais; Gordura Subcutânea/citologia; Fatores de Tempo; Transfecção

Palavras-chave

ADSCs; DDR1; adipose-derived stem cells; articular cartilage tissue engineering; chondrogenesis; discoidin domain receptor 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Receptores Proteína Tirosina Quinases / Condrócitos / Condrogênese / Gordura Subcutânea Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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