The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development.

Heikkinen, Aki T; Lignet, Floriane; Cutler, Paul; Parrott, Neil

Heikkinen, Aki T; Lignet, Floriane; Cutler, Paul; Parrott, Neil.

Afiliação

Heikkinen AT; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Lignet F; Pharmaceutical Sciences, Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Cutler P; Pharmaceutical Sciences, Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.
Parrott N; Pharmaceutical Sciences, Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland.

Proteomics Clin Appl ; 9(7-8): 732-44, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25676057

Assuntos

Descoberta de Drogas; Modelos Biológicos; Proteômica/métodos; Bibliotecas de Moléculas Pequenas/farmacocinética; Absorção Fisiológica; Animais; Humanos; Metabolismo; Proteoma/metabolismo

Palavras-chave

Absolute quantification; In vitro to in vivo extrapolation; Pharmacoproteomics; SRM; Targeted proteomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteômica / Bibliotecas de Moléculas Pequenas / Descoberta de Drogas / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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