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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Coll, Rebecca C; Robertson, Avril A B; Chae, Jae Jin; Higgins, Sarah C; Muñoz-Planillo, Raúl; Inserra, Marco C; Vetter, Irina; Dungan, Lara S; Monks, Brian G; Stutz, Andrea; Croker, Daniel E; Butler, Mark S; Haneklaus, Moritz; Sutton, Caroline E; Núñez, Gabriel; Latz, Eicke; Kastner, Daniel L; Mills, Kingston H G; Masters, Seth L; Schroder, Kate; Cooper, Matthew A; O'Neill, Luke A J.
Afiliação
  • Coll RC; 1] School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. [2] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
  • Robertson AA; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
  • Chae JJ; Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Higgins SC; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Muñoz-Planillo R; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • Inserra MC; 1] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. [2] School of Pharmacy, University of Queensland, Brisbane, Australia.
  • Vetter I; 1] Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia. [2] School of Pharmacy, University of Queensland, Brisbane, Australia.
  • Dungan LS; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Monks BG; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany.
  • Stutz A; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany.
  • Croker DE; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
  • Butler MS; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
  • Haneklaus M; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Sutton CE; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Núñez G; Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.
  • Latz E; 1] Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [3] German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Kastner DL; Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Mills KH; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Masters SL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Schroder K; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
  • Cooper MA; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
  • O'Neill LA; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Nat Med ; 21(3): 248-55, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25686105
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonas / Proteínas de Transporte / Encefalomielite Autoimune Experimental / Interleucina-1beta / Síndromes Periódicas Associadas à Criopirina / Inflamassomos / Compostos Heterocíclicos de 4 ou mais Anéis / Esclerose Múltipla Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonas / Proteínas de Transporte / Encefalomielite Autoimune Experimental / Interleucina-1beta / Síndromes Periódicas Associadas à Criopirina / Inflamassomos / Compostos Heterocíclicos de 4 ou mais Anéis / Esclerose Múltipla Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article