Turning peptides in comb silicone polymers.
J Pept Sci
; 21(3): 243-7, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25688748
We have recently reported on a new class of silicone-peptide' biopolymers obtained by polymerization of di-functionalized chlorodimethylsilyl hybrid peptides. Herein, we describe a related strategy based on dichloromethylsilane-derived peptides, which yield novel polymers with a polysiloxane backbone, comparable with a silicone-bearing pendent peptide chains. Interestingly, polymerization is chemoselective toward amino acids side-chains and proceeds in a single step in very mild conditions (neutral pH, water, and room temperature). As potential application, a cationic sequence was polymerized and used for antibacterial coating.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Polímeros
/
Siloxanas
/
Aminoácidos
/
Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article