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Turning peptides in comb silicone polymers.
Jebors, Said; Pinese, Coline; Nottelet, Benjamin; Parra, Karine; Amblard, Muriel; Mehdi, Ahmad; Martinez, Jean; Subra, Gilles.
Afiliação
  • Jebors S; Institut des Biomolécules Max Mousseron (IBMM), UMR5247 CNRS, ENSCM, Université de Montpellier, 15 avenue Charles Flahault, 34000, Montpellier, France; Institut Charles Gerhardt, UMR5253 CNRS, ENSCM, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier, France.
J Pept Sci ; 21(3): 243-7, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25688748
We have recently reported on a new class of silicone-peptide' biopolymers obtained by polymerization of di-functionalized chlorodimethylsilyl hybrid peptides. Herein, we describe a related strategy based on dichloromethylsilane-derived peptides, which yield novel polymers with a polysiloxane backbone, comparable with a silicone-bearing pendent peptide chains. Interestingly, polymerization is chemoselective toward amino acids side-chains and proceeds in a single step in very mild conditions (neutral pH, water, and room temperature). As potential application, a cationic sequence was polymerized and used for antibacterial coating.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Polímeros / Siloxanas / Aminoácidos / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Polímeros / Siloxanas / Aminoácidos / Antibacterianos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article