Effects of hyperbaric oxygen on Pseudomonas aeruginosa susceptibility to imipenem and macrophages.
Future Microbiol
; 10(2): 179-89, 2015.
Article
em En
| MEDLINE
| ID: mdl-25689530
ABSTRACT
BACKGROUND:
The seriousness to treat burn wounds infected with Pseudomonas aeruginosa led us to examine whether the effect of the carbapenem antibiotic imipenem is enhanced by hyperbaric oxygen (HBO). MATERIALS &METHODS:
The effects of HBO (100% O2, 3 ATA, 5 h) in combination with imipenen on bacterial counts of six isolates of P. aeruginosa and bacterial ultrastructure were investigated. Infected macrophages were exposed to HBO (100% O2, 3 ATA, 90 min) and the production of reactive oxygen species monitored.RESULTS:
HBO enhanced the effects of imipenen. HBO increased superoxide anion production by macrophages and likely kills bacteria by oxidative mechanisms.CONCLUSION:
HBO in combination with imipenem can be used to kill P. aeruginosa in vitro and such treatment may be beneficial for the patients with injuries containing the P. aeruginosa.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pseudomonas aeruginosa
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Imipenem
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Oxigenoterapia Hiperbárica
/
Macrófagos
/
Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article