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HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3ß/PTEN/Akt axis.
Wang, Guohua; Shi, Yejie; Jiang, Xiaoyan; Leak, Rehana K; Hu, Xiaoming; Wu, Yun; Pu, Hongjian; Li, Wei-Wei; Tang, Bo; Wang, Yun; Gao, Yanqin; Zheng, Ping; Bennett, Michael V L; Chen, Jun.
Afiliação
  • Wang G; State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China; Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA 15213;
  • Shi Y; Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA 15213; Geriatric Research, Education, and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261;
  • Jiang X; State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China;
  • Leak RK; Division of Pharmaceutical Sciences, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282; and.
  • Hu X; Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA 15213; Geriatric Research, Education, and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261;
  • Wu Y; Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA 15213; Geriatric Research, Education, and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261;
  • Pu H; State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China; Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA 15213;
  • Li WW; State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China;
  • Tang B; State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China;
  • Wang Y; State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China;
  • Gao Y; State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China; Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA 15213;
  • Zheng P; State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China;
  • Bennett MV; Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461 michael.bennett@einstein.yu.edu chenj2@upmc.edu.
  • Chen J; State Key Laboratory of Medical Neurobiology and Institute of Brain Science, Fudan University, Shanghai 200032, China; Center of Cerebrovascular Disease Research, University of Pittsburgh, Pittsburgh, PA 15213; Geriatric Research, Education, and Clinical Center, Veterans Affairs Pittsburgh Health Ca
Proc Natl Acad Sci U S A ; 112(9): 2853-8, 2015 Mar 03.
Article em En | MEDLINE | ID: mdl-25691750
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Lesões Encefálicas / Microglia / Quinase 3 da Glicogênio Sintase / PTEN Fosfo-Hidrolase / Proteínas Proto-Oncogênicas c-akt / Inibidores de Histona Desacetilases / Substância Branca / Hidroxilaminas / Macrófagos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Lesões Encefálicas / Microglia / Quinase 3 da Glicogênio Sintase / PTEN Fosfo-Hidrolase / Proteínas Proto-Oncogênicas c-akt / Inibidores de Histona Desacetilases / Substância Branca / Hidroxilaminas / Macrófagos Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article