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CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.
Khairnar, Vishal; Duhan, Vikas; Maney, Sathish Kumar; Honke, Nadine; Shaabani, Namir; Pandyra, Aleksandra A; Seifert, Marc; Pozdeev, Vitaly; Xu, Haifeng C; Sharma, Piyush; Baldin, Fabian; Marquardsen, Florian; Merches, Katja; Lang, Elisabeth; Kirschning, Carsten; Westendorf, Astrid M; Häussinger, Dieter; Lang, Florian; Dittmer, Ulf; Küppers, Ralf; Recher, Mike; Hardt, Cornelia; Scheffrahn, Inka; Beauchemin, Nicole; Göthert, Joachim R; Singer, Bernhard B; Lang, Philipp A; Lang, Karl S.
Afiliação
  • Khairnar V; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany.
  • Duhan V; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany.
  • Maney SK; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.
  • Honke N; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.
  • Shaabani N; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.
  • Pandyra AA; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany.
  • Seifert M; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstrasse 173, Essen 45122, Germany.
  • Pozdeev V; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.
  • Xu HC; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.
  • Sharma P; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany.
  • Baldin F; Clinic for Primary Immunodeficiency, Medical Outpatient Unit and Immunodeficiency Laboratory, Department of Biomedicine, University Hospital, Basel 4031, Switzerland.
  • Marquardsen F; Clinic for Primary Immunodeficiency, Medical Outpatient Unit and Immunodeficiency Laboratory, Department of Biomedicine, University Hospital, Basel 4031, Switzerland.
  • Merches K; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Department of Physiology I, University of Tuebingen, Gmelinstrasse 5, Tuebingen 72076, Germany.
  • Lang E; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.
  • Kirschning C; Institute of Medical Microbiology, Faculty of Medicine, University Hospital Essen, Hufelandstrasse 55, Essen 45122, Germany.
  • Westendorf AM; Institute of Medical Microbiology, Faculty of Medicine, University Hospital Essen, Hufelandstrasse 55, Essen 45122, Germany.
  • Häussinger D; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.
  • Lang F; Department of Physiology I, University of Tuebingen, Gmelinstrasse 5, Tuebingen 72076, Germany.
  • Dittmer U; Institute of Virology, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany.
  • Küppers R; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Virchowstrasse 173, Essen 45122, Germany.
  • Recher M; Clinic for Primary Immunodeficiency, Medical Outpatient Unit and Immunodeficiency Laboratory, Department of Biomedicine, University Hospital, Basel 4031, Switzerland.
  • Hardt C; Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany.
  • Scheffrahn I; Clinic of Gastroenterology and Hepatology, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany.
  • Beauchemin N; Rosalind and Morris Goodman Cancer Centre, Departments of Biochemistry, Medicine and Oncology, McIntyre Medical Science Building, Montreal, Quebec, Canada H3G 1Y6.
  • Göthert JR; Department of Hematology, West German Cancer Center (WTZ), University Hospital Essen, Hufelandstrasse 55, Essen 45147, Germany.
  • Singer BB; Institute of Anatomy, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany.
  • Lang PA; 1] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany [2] Department of Molecular Medicine II, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, Düsseldorf 40225, Germany.
  • Lang KS; 1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.
Nat Commun ; 6: 6217, 2015 Feb 18.
Article em En | MEDLINE | ID: mdl-25692415
ABSTRACT
B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influence on the proliferation of B cells, expression of CEACAM1 induces survival of proliferating B cells via the BTK/Syk/NF-κB-axis. The absence of this signalling cascade in naive Ceacam1(-/-) mice limits the survival of B cells. During systemic infection with cytopathic vesicular stomatitis virus, Ceacam1(-/-) mice can barely induce neutralizing antibody responses and die early after infection. We find, therefore, that CEACAM1 is a crucial regulator of B-cell survival, influencing B-cell numbers and protective antiviral antibody responses.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Antígeno Carcinoembrionário / Anticorpos Antivirais Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Antígeno Carcinoembrionário / Anticorpos Antivirais Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article