Metformin inhibits 7,12-dimethylbenz[a]anthracene-induced breast carcinogenesis and adduct formation in human breast cells by inhibiting the cytochrome P4501A1/aryl hydrocarbon receptor signaling pathway.

Maayah, Zaid H; Ghebeh, Hazem; Alhaider, Abdulqader A; El-Kadi, Ayman O S; Soshilov, Anatoly A; Denison, Michael S; Ansari, Mushtaq Ahmad; Korashy, Hesham M

Maayah, Zaid H; Ghebeh, Hazem; Alhaider, Abdulqader A; El-Kadi, Ayman O S; Soshilov, Anatoly A; Denison, Michael S; Ansari, Mushtaq Ahmad; Korashy, Hesham M.

Afiliação

Maayah ZH; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Ghebeh H; Stem Cell & Tissue Re-Engineering, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Alhaider AA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; Camel Biomedical Research Unit, College of Pharmacy and Medicine, King Saud University, Riyadh 11451, Saudi Arabia.
El-Kadi AO; Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
Soshilov AA; Department of Environmental Toxicology, University of California at Davis, Davis, CA 95616, USA.
Denison MS; Department of Environmental Toxicology, University of California at Davis, Davis, CA 95616, USA.
Ansari MA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Korashy HM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: hkorashy@ksu.edu.sa.

Toxicol Appl Pharmacol ; 284(2): 217-26, 2015 Apr 15.

Article em En | MEDLINE | ID: mdl-25697376

Assuntos

9,10-Dimetil-1,2-benzantraceno/análogos & derivados; Anticarcinógenos/farmacologia; Neoplasias da Mama/prevenção & controle; Citocromo P-450 CYP1A1/antagonistas & inibidores; Adutos de DNA/biossíntese; Metformina/farmacologia; Receptores de Hidrocarboneto Arílico/antagonistas & inibidores; 9,10-Dimetil-1,2-benzantraceno/administração & dosagem; 9,10-Dimetil-1,2-benzantraceno/metabolismo; Animais; Neoplasias da Mama/induzido quimicamente; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Carcinogênese/efeitos dos fármacos; Carcinógenos/administração & dosagem; Carcinógenos/metabolismo; Linhagem Celular Tumoral; Citocromo P-450 CYP1A1/metabolismo; Feminino; Guanina/análogos & derivados; Guanina/metabolismo; Humanos; Camundongos; NAD(P)H Desidrogenase (Quinona)/metabolismo; RNA Mensageiro/metabolismo; Receptores de Hidrocarboneto Arílico/metabolismo; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

AhR; Breast cancer; Cytochrome P4501A1; DNA damage; MCF10A cells; Metformin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Anticarcinógenos / Receptores de Hidrocarboneto Arílico / Adutos de DNA / Citocromo P-450 CYP1A1 / 9,10-Dimetil-1,2-benzantraceno / Metformina Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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