Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity.
Org Lett
; 17(5): 1110-3, 2015 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-25706347
Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-ß1-induced human renal proximal tubular cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Ganoderma
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article