Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8⺠T cells responding to infection.
Nat Immunol
; 16(4): 406-14, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25706747
We report that oral infection with Yersinia pseudotuberculosis results in the development of two distinct populations of pathogen-specific CD8(+) tissue-resident memory T cells (TRM cells) in the lamina propria. CD103(-) T cells did not require transforming growth factor-ß (TGF-ß) signaling but were true resident memory cells. Unlike CD103(+)CD8(+) T cells, which were TGF-ß dependent and were scattered in the tissue, CD103(-)CD8(+) T cells clustered with CD4(+) T cells and CX3CR1(+) macrophages and/or dendritic cells around areas of bacterial infection. CXCR3-dependent recruitment of cells to inflamed areas was critical for development of the CD103(-) population and pathogen clearance. Our studies have identified the 'preferential' development of CD103(-) TRM cells in inflammatory microenvironments within the lamina propria and suggest that this subset has a critical role in controlling infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Yersinia pseudotuberculosis
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Antígenos CD
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Linfócitos T CD8-Positivos
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Cadeias alfa de Integrinas
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Mucosa Intestinal
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article