P388 leukemia in CDF1 mice as the test system for studies of tumor-associated neoangiogenesis and hypercoagulation.
Bull Exp Biol Med
; 158(4): 497-9, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25708334
ABSTRACT
Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtornos da Coagulação Sanguínea
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Leucemia P388
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Fator A de Crescimento do Endotélio Vascular
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Neovascularização Patológica
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article