Bioactive Metabolites from the Fruits of Psoralea corylifolia.
J Nat Prod
; 78(4): 666-73, 2015 Apr 24.
Article
em En
| MEDLINE
| ID: mdl-25710081
ABSTRACT
Twenty-four metabolites, including seven new compounds (1-7), were isolated from the dried fruits of Psoralea corylifolia. On the basis of combined spectroscopic and chemical analysis, the new compounds were determined to be six flavonoids (1-6) and a meroterpenoid (7). The absolute configurations of the natural products obtained, including the previously undetermined 16 and 17, were assigned by several methods, such as NOE spectroscopy, optical rotation, and CD spectroscopy. Several of these compounds exhibited moderate inhibitory activity toward Staphylococcus mutans-derived SrtA (2, 6, and 16) and significant stimulation of SIRT1 activity (2, 3, and 15).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
/
Flavonoides
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Psoralea
/
Frutas
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article