Robust, fully automatic delineation of the head contour by stereotactical normalization for attenuation correction according to Chang in dopamine transporter scintigraphy.
Eur Radiol
; 25(9): 2709-17, 2015 Sep.
Article
em En
| MEDLINE
| ID: mdl-25716941
ABSTRACT
OBJECTIVES:
Chang's method, the most widely used attenuation correction (AC) in brain single-photon emission computed tomography (SPECT), requires delineation of the outer contour of the head. Manual and automatic threshold-based methods are prone to errors due to variability of tracer uptake in the scalp. The present study proposes a new method for fully automated delineation of the head based on stereotactical normalization. The method was validated for SPECT with I-123-ioflupane.METHODS:
The new method was compared to threshold-based delineation in 62 unselected patients who had received I-123-ioflupane SPECT at one of 3 centres. The impact on diagnostic power was tested for semi-quantitative analysis and visual reading of the SPECT images (six independent readers).RESULTS:
The two delineation methods produced highly consistent semi-quantitative results. This was confirmed by receiver operating characteristic analyses in which the putamen specific-to-background ratio achieved highest area under the curve with negligible effect of the delineationmethod:
0.935 versus 0.938 for stereotactical normalization and threshold-based delineation, respectively. Visual interpretation of DVR images was also not affected by the delineation method.CONCLUSIONS:
Delineation of the head contour by stereotactical normalization appears useful for Chang AC in I-123-ioflupane SPECT. It is robust and does not require user interaction. KEY POINTS â¢Chang attenuation correction in brain SPECT requires delineation of the head contour. â¢Manual and threshold-based methods are prone to errors. â¢The study proposes a fully-automated method for delineation based on stereotactical normalization. â¢The method is shown to work reliably in I-123-ioflupane SPECT. â¢It might improve the workflow of I-123-ioflupane SPECT in everyday patient care.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Tomografia Computadorizada de Emissão de Fóton Único
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Técnicas Estereotáxicas
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Proteínas da Membrana Plasmática de Transporte de Dopamina
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Cabeça
Tipo de estudo:
Diagnostic_studies
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Guideline
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Prognostic_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article