Stereoselective construction of 2,6-cis-disubstituted tetrahydropyrans via intramolecular amide enolate alkylation: total synthesis of (-)-centrolobine.
J Org Chem
; 80(6): 3315-20, 2015 Mar 20.
Article
em En
| MEDLINE
| ID: mdl-25723100
ABSTRACT
A highly stereoselective construction of 2,6-cis-disubstituted tetrahydropyrans was achieved by using an intramolecular amide enolate alkylation with KHMDS. The efficiency and practicality of this methodology was successfully demonstrated in the total synthesis of (-)-centrolobine (1).
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1
Base de dados:
MEDLINE
Assunto principal:
Piranos
/
Amidas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article