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Chronic baclofen desensitizes GABA(B)-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain.
Keegan, Bradley M T; Beveridge, Thomas J R; Pezor, Jeffrey J; Xiao, Ruoyu; Sexton, Tammy; Childers, Steven R; Howlett, Allyn C.
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  • Keegan BM; Center for the Neurobiology of Addiction Treatment, Winston-Salem, NC 27157, USA; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Beveridge TJ; Center for the Neurobiology of Addiction Treatment, Winston-Salem, NC 27157, USA; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Pezor JJ; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Department of Chemistry, Wake Forest University, Winston-Salem, NC 27157, USA.
  • Xiao R; Center for the Neurobiology of Addiction Treatment, Winston-Salem, NC 27157, USA; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Sexton T; Center for the Neurobiology of Addiction Treatment, Winston-Salem, NC 27157, USA; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Childers SR; Center for the Neurobiology of Addiction Treatment, Winston-Salem, NC 27157, USA; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Howlett AC; Center for the Neurobiology of Addiction Treatment, Winston-Salem, NC 27157, USA; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Electronic address: ahowlett@wakehealth.edu.
Neuropharmacology ; 95: 492-502, 2015 Aug.
Article em En | MEDLINE | ID: mdl-25724082
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Baclofeno / Encéfalo / Receptores de GABA-B / Proteínas de Ligação ao GTP / Agonistas dos Receptores de GABA-B Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Baclofeno / Encéfalo / Receptores de GABA-B / Proteínas de Ligação ao GTP / Agonistas dos Receptores de GABA-B Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article