Decreased mitochondrial bioenergetics and calcium buffering capacity in the basal ganglia correlates with motor deficits in a nonhuman primate model of aging.

Pandya, Jignesh D; Grondin, Richard; Yonutas, Heather M; Haghnazar, Hamed; Gash, Don M; Zhang, Zhiming; Sullivan, Patrick G

Decreased mitochondrial bioenergetics and calcium buffering capacity in the basal ganglia correlates with motor deficits in a nonhuman primate model of aging.

Pandya, Jignesh D; Grondin, Richard; Yonutas, Heather M; Haghnazar, Hamed; Gash, Don M; Zhang, Zhiming; Sullivan, Patrick G.

Afiliação

Pandya JD; Spinal Cord and Brain Injury Research Center, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA.
Grondin R; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA.
Yonutas HM; Spinal Cord and Brain Injury Research Center, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA.
Haghnazar H; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA.
Gash DM; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA.
Zhang Z; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA.
Sullivan PG; Spinal Cord and Brain Injury Research Center, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA; Department of Anatomy and Neurobiology, The University of Kentucky Chandler College of Medicine, Lexington, KY, USA. Electronic address: patsull@uky.edu.

Neurobiol Aging ; 36(5): 1903-13, 2015 May.

Article em En | MEDLINE | ID: mdl-25726361

Assuntos

Envelhecimento/metabolismo; Envelhecimento/fisiologia; Gânglios da Base/metabolismo; Gânglios da Base/ultraestrutura; Metabolismo Energético/fisiologia; Mitocôndrias/metabolismo; Transtornos Motores/metabolismo; Transtornos Motores/fisiopatologia; Trifosfato de Adenosina/biossíntese; Animais; Modelos Animais de Doenças; Feminino; Macaca mulatta; Proteínas de Transporte da Membrana Mitocondrial; Poro de Transição de Permeabilidade Mitocondrial; Atividade Motora; Transtornos Motores/etiologia; Movimento; Doenças Neurodegenerativas; Complexo Piruvato Desidrogenase/metabolismo

Palavras-chave

Aging; Alzheimer's disease; Brain; Calcium buffering; Mitochondria; Mitochondrial permeability transition pore; Parkinson's disease; Parkinsonism; Pyruvate dehydrogenase complex enzyme activity; Respiration; Rhesus monkeys

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gânglios da Base / Envelhecimento / Metabolismo Energético / Transtornos Motores / Mitocôndrias Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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