Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking.
Cancer Biol Ther
; 16(4): 589-601, 2015.
Article
em En
| MEDLINE
| ID: mdl-25729885
Palavras-chave
ConA concanavalin; DLBCL diffuse large B cell lymphoma; MAA Maackia amurensis agglutinin; ORPs oxysterol-binding protein related family proteins; PDK1 phosphoinositide-dependent kinase 1; PIP3 phosphatidylinositol (3,4,5)-triphosphate; PNA peanut agglutinin; PTEN phosphatase and tensin homolog; SA-J schweinfurthin A-J; TGN trans-Golgi-network; WGA wheat germ agglutinin; diffuse large B cell lymphoma; mTOR mammalian target of rapamycin; mTOR-AKT signaling; natural compounds; schweinfurthins; trans-Golgi-network
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Transdução de Sinais
/
Rede trans-Golgi
/
Proliferação de Células
/
Proteínas Proto-Oncogênicas c-akt
/
Bibliotecas de Moléculas Pequenas
/
Serina-Treonina Quinases TOR
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article