Secondary breast angiosarcoma and paclitaxel-dependent prolonged disease control: report of two cases and review of the literature.
Tumori
; 101(2): e60-3, 2015 Apr 28.
Article
em En
| MEDLINE
| ID: mdl-25744864
ABSTRACT
Secondary breast angiosarcomas are a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease. Among the drugs with demonstrated activity, taxane derivatives are one of the most effective histology-driven treatments against angiosarcomas. We report two cases of secondary breast angiosarcoma, both characterized by a very peculiar behavior towards paclitaxel. Both patients showed local recurrence of angiosarcoma after primary surgery, and they achieved complete remission following treatment with weekly paclitaxel. When a locoregional recurrence was observed as a result of a brief treatment interruption or a treatment delay, a new complete remission was rapidly achieved with the resumption of the drug, without evidence of any significant adverse effects.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Paclitaxel
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Hemangiossarcoma
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Recidiva Local de Neoplasia
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Antineoplásicos Fitogênicos
Limite:
Aged80
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article