No impact of passive smoke on the somatic profile of lung cancers in never-smokers.
Eur Respir J
; 45(5): 1415-25, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25745045
ABSTRACT
EGFR and HER2 mutations and ALK rearrangement are known to be related to lung cancer in never-smokers, while KRAS, BRAF and PIK3CA mutations are typically observed among smokers. There is still debate surrounding whether never-smokers exposed to passive smoke exhibit a "smoker-like" somatic profile compared with unexposed never-smokers. Passive smoke exposure was assessed in the French BioCAST/IFCT-1002 never-smoker lung cancer cohort and routine molecular profiles analyses were compiled. Of the 384 patients recruited into BioCAST, 319 were tested for at least one biomarker and provided data relating to passive smoking. Overall, 219 (66%) reported having been exposed to passive smoking. No significant difference was observed between mutation frequency and passive smoke exposure (EGFR mutation 46% in never exposed versus 41% in ever exposed; KRAS 7% versus 7%; ALK 13% versus 11%; HER2 4% versus 5%; BRAF 6% versus 5%; PIK3CA 4% versus 2%). We observed a nonsignificant trend for a negative association between EGFR mutation and cumulative duration of passive smoke exposure. No association was found for other biomarkers. There is no clear association between passive smoke exposure and somatic profile in lifelong, never-smoker lung cancer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poluição por Fumaça de Tabaco
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Proteínas Proto-Oncogênicas p21(ras)
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Receptores Proteína Tirosina Quinases
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Receptores ErbB
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Neoplasias Pulmonares
Tipo de estudo:
Clinical_trials
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Observational_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article