Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons.
Biochem Biophys Res Commun
; 459(3): 504-8, 2015 Apr 10.
Article
em En
| MEDLINE
| ID: mdl-25747715
ABSTRACT
Cadherin-6B induces bone morphogenetic protein (BMP) signaling to promote the epithelial mesenchymal transition (EMT) in the neural crest. We have previously found that knockdown of Cadherin-6B inhibits both BMP signaling and the emigration of the early pre-migratory neural crest cells from the dorsal neural tube. In this study, we found that inhibition of BMP signaling in the neural tube, mediated by the ectopic expression of Smad-6 or Noggin, decreased the size of the Islet-1-positive dorsal cell population. Knockdown or loss of function of Cadherin-6B suppressed the generation of Islet-1-expressing cells in the dorsal neural tube, but not the Lim-1/2 positive dorsal cell population. Our results thus indicate that Cadherin-6B is necessary for the generation of Islet-1-positive dorsal interneurons, as well as the initiation of pre-migratory neural crest cell emigration.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Caderinas
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Proteínas Aviárias
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Proteínas com Homeodomínio LIM
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Interneurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article