3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of &#945;-synuclein in PC12 cells.

Xue, Danfeng; Wang, Quanxin; Chen, Ziheng; Cai, Lei; Bao, Li; Qi, Qiuyue; Liu, Lei; Wang, Xiaohui; Jin, Haijing; Wang, Jun; Wu, Hao; Liu, Hongwei; Chen, Quan

3-Anhydro-6-hydroxy-ophiobolin A, a fungal sesterterpene from Bipolaris oryzae induced autophagy and promoted the degradation of α-synuclein in PC12 cells.

Xue, Danfeng; Wang, Quanxin; Chen, Ziheng; Cai, Lei; Bao, Li; Qi, Qiuyue; Liu, Lei; Wang, Xiaohui; Jin, Haijing; Wang, Jun; Wu, Hao; Liu, Hongwei; Chen, Quan.

Afiliação

Xue D; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100101, China.
Wang Q; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Chen Z; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100101, China.
Cai L; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Bao L; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Qi Q; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
Liu L; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100101, China.
Wang X; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Jin H; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Wang J; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Wu H; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100101, China. Electronic address: wuhao@ioz.ac.cn.
Liu H; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: liuhw@im.ac.cn.
Chen Q; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100101, China; Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin

Bioorg Med Chem Lett ; 25(7): 1464-70, 2015 Apr 01.

Article em En | MEDLINE | ID: mdl-25748161

Assuntos

Ascomicetos/química; Autofagia/efeitos dos fármacos; Modificação Traducional de Proteínas/efeitos dos fármacos; Proteólise/efeitos dos fármacos; Sesterterpenos/farmacologia; alfa-Sinucleína/metabolismo; Animais; Relação Dose-Resposta a Droga; Células HeLa; Humanos; Conformação Molecular; Células PC12; Ratos; Sesterterpenos/química; Sesterterpenos/isolamento & purificação; Relação Estrutura-Atividade

Palavras-chave

3-Anhydro-6-hydroxy-ophiobolin A; Autophagy; ROS; α-Synuclein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ascomicetos / Autofagia / Modificação Traducional de Proteínas / Alfa-Sinucleína / Sesterterpenos / Proteólise Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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