Prevalence of shingles and its association with PTSD among HIV-infected women in Rwanda.
BMJ Open
; 5(3): e005506, 2015 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-25748413
ABSTRACT
OBJECTIVE:
To examine the prevalence of reported shingles in the last 6â months and its association with post-traumatic stress disorder (PTSD), depression and severity of HIV disease in Rwandan women with HIV. SETTINGS This cross-sectional study was conducted as part of the Rwanda Women's Interassociation Study and Assessment (RWISA), an observational cohort study designed to assess the impact of HIV and residual factors from experiencing rape in the 1994 genocide in Rwandan women. Participants were recruited through grassroots women's associations of people living with HIV infection and clinical care sites for HIV infection. Most participants (58.5%, n=405/692) had PTSD.PARTICIPANTS:
This cross-sectional analysis was conducted in 710 HIV-infected women enrolled in RWISA. Inclusion criteria were age >15â years, informed consent, HIV test, ability to complete the interview in the local language, travel to and from the research site and participate in a baseline outpatient visit, and being naive to antiretroviral therapy at enrolment. PRIMARY AND SECONDARY OUTCOMEMEASURES:
The outcome of interest was self-reported shingles in the past 6â months. The exposure was PTSD defined using the cross-culturally validated Harvard Trauma Questionnaire.RESULTS:
Overall prevalence of reported shingles in the past 6â months was 12.5% (n=89/710). There was an inverse relationship between shingles prevalence and immunological status 7.6%, 12.3% and 16.7% of women with CD4 >350, 200-350 and <200â cells/µL, respectively, reported singles (p=0.01). In multivariate analysis, PTSD (aOR 1.7; 95% CI 1.02 to 2.89) and low CD4 (aOR 2.4; 95% CI 1.23 to 4.81) were independently associated with reported shingles in the past 6â months.CONCLUSIONS:
Our study found a significant independent relationship between PTSD and reported shingles, suggesting that PTSD may be associated with immune compromise that can result in herpes zoster reactivation. Further study is needed. It also confirmed previous findings of a strong relationship between shingles and greater immunosuppression in women with HIV infection.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estupro
/
Transtornos de Estresse Pós-Traumáticos
/
Infecções por HIV
/
Genocídio
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Herpes Zoster
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article