Redox-responsive polymer-drug conjugates based on doxorubicin and chitosan oligosaccharide-g-stearic acid for cancer therapy.

Su, Yigang; Hu, Yingwen; Du, Yongzhong; Huang, Xuan; He, Jiabei; You, Jian; Yuan, Hong; Hu, Fuqiang

Su, Yigang; Hu, Yingwen; Du, Yongzhong; Huang, Xuan; He, Jiabei; You, Jian; Yuan, Hong; Hu, Fuqiang.

Afiliação

Su Y; College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, People's Republic of China.
Hu Y; College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, People's Republic of China.
Du Y; College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, People's Republic of China.
Huang X; Department of Pharmacy, School of Medicine Science, Jiaxing University, Jiaxing, Zhejiang 314001, People's Republic of China.
He J; College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, People's Republic of China.
You J; College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, People's Republic of China.
Yuan H; College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, People's Republic of China.
Hu F; College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058, People's Republic of China.

Mol Pharm ; 12(4): 1193-202, 2015 Apr 06.

Article em En | MEDLINE | ID: mdl-25751168

Assuntos

Antineoplásicos/administração & dosagem; Quitosana/química; Doxorrubicina/administração & dosagem; Resistencia a Medicamentos Antineoplásicos; Neoplasias/tratamento farmacológico; Oligossacarídeos/química; Ácidos Esteáricos/química; Animais; Antineoplásicos/química; Cromatografia Líquida; Dissulfetos/química; Sistemas de Liberação de Medicamentos; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Concentração Inibidora 50; Células MCF-7; Espectroscopia de Ressonância Magnética; Masculino; Espectrometria de Massas; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Micelas; Microscopia Confocal; Oxirredução; Tamanho da Partícula; Polímeros/química

Palavras-chave

chitosan; controlled release; drug resistance; polymer−drug conjugates; redox-responsive

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligossacarídeos / Ácidos Esteáricos / Doxorrubicina / Resistencia a Medicamentos Antineoplásicos / Quitosana / Neoplasias / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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