The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission.
EMBO Rep
; 16(5): 590-8, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25755256
ABSTRACT
Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transporter, and its transport activity is required for the subsequent conversion of L-serine into glycine in vivo. Asc-1 is a novel regulator of glycine metabolism and a candidate for hyperekplexia disorders.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Transmissão Sináptica
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Sistema y/ de Transporte de Aminoácidos
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Glicina
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article