Inhibition of NF-&#954;B activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress.

Yu, Xiao-Jing; Zhang, Dong-Mei; Jia, Lin-Lin; Qi, Jie; Song, Xin-Ai; Tan, Hong; Cui, Wei; Chen, Wensheng; Zhu, Guo-Qing; Qin, Da-Nian; Kang, Yu-Ming

Inhibition of NF-κB activity in the hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy by modulating cytokines and attenuating oxidative stress.

Yu, Xiao-Jing; Zhang, Dong-Mei; Jia, Lin-Lin; Qi, Jie; Song, Xin-Ai; Tan, Hong; Cui, Wei; Chen, Wensheng; Zhu, Guo-Qing; Qin, Da-Nian; Kang, Yu-Ming.

Afiliação

Yu XJ; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Zhang DM; Department of Physiology, Dalian Medical University, Dalian 116044, China.
Jia LL; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Qi J; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Song XA; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Tan H; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Cui W; Department of Endocrinology and Metabolism, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Chen W; Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Zhu GQ; Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing 210029, China.
Qin DN; Department of Physiology, Shantou University Medical College, Shantou 515041, China. Electronic address: dnqin@stu.edu.cn.
Kang YM; Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China. Electronic address: ykang@mail.xjtu.edu.cn.

Toxicol Appl Pharmacol ; 284(3): 315-22, 2015 May 01.

Article em En | MEDLINE | ID: mdl-25759242

Assuntos

Cardiomegalia/prevenção & controle; Citocinas/metabolismo; Hipertensão/tratamento farmacológico; Mediadores da Inflamação/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Núcleo Hipotalâmico Paraventricular/efeitos dos fármacos; Pirrolidinas/farmacologia; Tiocarbamatos/farmacologia; Fator de Transcrição RelA/antagonistas & inibidores; Animais; Pressão Arterial/efeitos dos fármacos; Biomarcadores/metabolismo; Cardiomegalia/etiologia; Cardiomegalia/imunologia; Cardiomegalia/metabolismo; Cardiomegalia/fisiopatologia; Modelos Animais de Doenças; Hipertensão/complicações; Hipertensão/imunologia; Hipertensão/metabolismo; Hipertensão/fisiopatologia; Núcleo Hipotalâmico Paraventricular/imunologia; Núcleo Hipotalâmico Paraventricular/metabolismo; Ratos Endogâmicos SHR; Ratos Endogâmicos WKY; Transdução de Sinais/efeitos dos fármacos; Sistema Nervoso Simpático/efeitos dos fármacos; Sistema Nervoso Simpático/metabolismo; Sistema Nervoso Simpático/fisiopatologia; Fatores de Tempo; Fator de Transcrição RelA/metabolismo

Palavras-chave

Cardiac hypertrophy; Hypertension; Hypothalamic paraventricular nucleus; NF-κB; Neurohormonal excitation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Núcleo Hipotalâmico Paraventricular / Pirrolidinas / Tiocarbamatos / Citocinas / Cardiomegalia / Estresse Oxidativo / Mediadores da Inflamação / Fator de Transcrição RelA / Hipertensão Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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