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Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies.
Galasiti Kankanamalage, Anushka C; Kim, Yunjeong; Weerawarna, Pathum M; Uy, Roxanne Adeline Z; Damalanka, Vishnu C; Mandadapu, Sivakoteswara Rao; Alliston, Kevin R; Mehzabeen, Nurjahan; Battaile, Kevin P; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C.
Afiliação
  • Galasiti Kankanamalage AC; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States.
  • Weerawarna PM; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States.
  • Uy RA; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States.
  • Damalanka VC; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States.
  • Mandadapu SR; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States.
  • Alliston KR; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States.
  • Mehzabeen N; §Protein Structure Laboratory,The University of Kansas, Lawrence, Kansas 66047, United States.
  • Battaile KP; ∥IMCA-CAT, Hauptman-Woodward Medical Research Institute, APS Argonne National Laboratory, Argonne, Illinois 60439, United States.
  • Lovell S; §Protein Structure Laboratory,The University of Kansas, Lawrence, Kansas 66047, United States.
  • Groutas WC; †Department of Chemistry, Wichita State University, 1845 North Fairmount Avenue, Wichita, Kansas 67260, United States.
J Med Chem ; 58(7): 3144-55, 2015 Apr 09.
Article em En | MEDLINE | ID: mdl-25761614
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Inibidores de Proteases / Proteínas Virais / Norovirus Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Inibidores de Proteases / Proteínas Virais / Norovirus Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article