Mebamamides A and B, Cyclic Lipopeptides Isolated from the Green Alga Derbesia marina.
J Nat Prod
; 78(4): 901-8, 2015 Apr 24.
Article
em En
| MEDLINE
| ID: mdl-25768725
ABSTRACT
Mebamamides A and B, new lipopeptides with four d-amino acid residues and a 3,8-dihydroxy-9-methyldecanoic acid residue, were isolated from the green alga Derbesia marina. Their gross structures were elucidated by spectroscopic and ESI-ITMS analyses. The absolute configurations except for the two leucines were revealed based on chiral-phase HPLC analyses of the acid hydrolysate and a modified Mosher's method. A distinction between D-Leu and L-Leu in the sequence was established by the application of a dansyl-Edman method to the partial acid hydrolysate. Mebamamide A did not exhibit any growth inhibitory activity against HeLa and HL60 cells at 10 µM, and mebamamide B did not exhibit any growth inhibitory activity against those cells at 100 µM. Additionally, it was suggested that mebamamide B induced the differentiation of HL60 cells into macrophage-like cells at 100 µM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Clorófitas
/
Lipopeptídeos
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article