Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics.

Morad, Samy A F; Tan, Su-Fern; Feith, David J; Kester, Mark; Claxton, David F; Loughran, Thomas P; Barth, Brian M; Fox, Todd E; Cabot, Myles C

Morad, Samy A F; Tan, Su-Fern; Feith, David J; Kester, Mark; Claxton, David F; Loughran, Thomas P; Barth, Brian M; Fox, Todd E; Cabot, Myles C.

Afiliação

Morad SA; Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA.
Tan SF; Department of Medicine, Hematology/Oncology, University of Virginia, Charlottesville, VA 22908-0716, USA.
Feith DJ; Department of Medicine, Hematology/Oncology, University of Virginia, Charlottesville, VA 22908-0716, USA; University of Virginia Cancer Center, Charlottesville, VA 22908-0716, USA.
Kester M; University of Virginia Cancer Center, Charlottesville, VA 22908-0716, USA.
Claxton DF; Penn State Hershey Cancer Institute, Hershey, PA 17033, USA.
Loughran TP; Department of Medicine, Hematology/Oncology, University of Virginia, Charlottesville, VA 22908-0716, USA; University of Virginia Cancer Center, Charlottesville, VA 22908-0716, USA.
Barth BM; Penn State Hershey Cancer Institute, Hershey, PA 17033, USA.
Fox TE; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908-0001, USA.
Cabot MC; Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA. Electronic address: cabotm@ecu.edu.

Biochim Biophys Acta ; 1851(7): 919-28, 2015 Jul.

Article em En | MEDLINE | ID: mdl-25769964

Assuntos

Citotoxinas/farmacologia; Leucemia Mieloide Aguda/metabolismo; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Esfingolipídeos/metabolismo; Tamoxifeno/análogos & derivados; Tamoxifeno/farmacologia; Ativação Enzimática/efeitos dos fármacos; Antagonistas de Estrogênios/farmacologia; Células HL-60; Humanos; Leucemia Mieloide Aguda/patologia; Metabolismo dos Lipídeos/efeitos dos fármacos; Fosfotransferases (Aceptor do Grupo Álcool)/efeitos dos fármacos; Estilbenos/farmacologia; Células Tumorais Cultivadas

Palavras-chave

Ceramide; Leukemia; Sphingolipid metabolism; Tamoxifen; Triphenylethylenes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingolipídeos / Tamoxifeno / Leucemia Mieloide Aguda / Fosfotransferases (Aceptor do Grupo Álcool) / Citotoxinas Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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