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Increased brain bio-distribution and chemical stability and decreased immunogenicity of an engineered variant of GDNF.
Smith, Rosamund C; O'Bryan, Linda M; Mitchell, Pamela J; Leung, Donmienne; Ghanem, Mahmoud; Wilson, Jonathan M; Hanson, Jeff C; Sossick, Sandra; Cooper, Jane; Huang, Lihua; Merchant, Kalpana M; Lu, Jirong; O'Neill, Michael J.
Afiliação
  • Smith RC; Eli Lilly & Co., Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address: smith_ros@lilly.com.
  • O'Bryan LM; Eli Lilly & Co., Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address: o'bryan_linda_maureen@lilly.com.
  • Mitchell PJ; Eli Lilly & Co., Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address: mitchell_pamela@lilly.com.
  • Leung D; Eli Lilly & Co., Lilly Biotechnology Center, 10300 Campus Point Dr, Suite 200, San Diego, CA 92121, USA. Electronic address: leung_donmienne@lilly.com.
  • Ghanem M; Eli Lilly & Co., Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address: mahmoud.ghanem@siemens.com.
  • Wilson JM; Eli Lilly & Co., Tailored Therapeutics, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address: wilson_jonathan_matthew@lilly.com.
  • Hanson JC; Eli Lilly & Co., Information Technology, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address: hanson_jeffrey_c@lilly.com.
  • Sossick S; Eli Lilly & Co. Ltd, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK. Electronic address: sossick_sandra@lilly.com.
  • Cooper J; Eli Lilly & Co. Ltd, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK. Electronic address: cooper_jane_x1@lilly.com.
  • Huang L; Eli Lilly & Co., Bioproduct Research and Development, Indianapolis, IN 46285, USA. Electronic address: huang_lihua@lilly.com.
  • Merchant KM; Eli Lilly & Co., Tailored Therapeutics, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address: merchant.transthera@gmail.com.
  • Lu J; Eli Lilly & Co., Biotechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA. Electronic address: lu_jirong@lilly.com.
  • O'Neill MJ; Eli Lilly & Co. Ltd, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK. Electronic address: oneill_michael_j@lilly.com.
Exp Neurol ; 267: 165-76, 2015 May.
Article em En | MEDLINE | ID: mdl-25771799
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Fator Neurotrófico Derivado de Linhagem de Célula Glial / Fenômenos Imunogenéticos / Mutação Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Fator Neurotrófico Derivado de Linhagem de Célula Glial / Fenômenos Imunogenéticos / Mutação Tipo de estudo: Clinical_trials / Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article