Quantitative modeling of transcription factor binding specificities using DNA shape.

Zhou, Tianyin; Shen, Ning; Yang, Lin; Abe, Namiko; Horton, John; Mann, Richard S; Bussemaker, Harmen J; Gordân, Raluca; Rohs, Remo

Zhou, Tianyin; Shen, Ning; Yang, Lin; Abe, Namiko; Horton, John; Mann, Richard S; Bussemaker, Harmen J; Gordân, Raluca; Rohs, Remo.

Afiliação

Zhou T; Molecular and Computational Biology Program, Departments of Biological Sciences, Chemistry, Physics, and Computer Science, University of Southern California, Los Angeles, CA 90089;
Shen N; Departments of Pharmacology and Cancer Biology and Center for Genomic and Computational Biology, Duke University, Durham, NC 27708;
Yang L; Molecular and Computational Biology Program, Departments of Biological Sciences, Chemistry, Physics, and Computer Science, University of Southern California, Los Angeles, CA 90089;
Abe N; Departments of Biochemistry and Molecular Biophysics and.
Horton J; Center for Genomic and Computational Biology, Duke University, Durham, NC 27708; Biostatistics and Bioinformatics and.
Mann RS; Departments of Biochemistry and Molecular Biophysics and Systems Biology, Columbia University, New York, NY 10032; and.
Bussemaker HJ; Systems Biology, Columbia University, New York, NY 10032; and Department of Biological Sciences, Columbia University, New York, NY 10027.
Gordân R; Center for Genomic and Computational Biology, Duke University, Durham, NC 27708; Biostatistics and Bioinformatics and rohs@usc.edu raluca.gordan@duke.edu.
Rohs R; Molecular and Computational Biology Program, Departments of Biological Sciences, Chemistry, Physics, and Computer Science, University of Southern California, Los Angeles, CA 90089; rohs@usc.edu raluca.gordan@duke.edu.

Proc Natl Acad Sci U S A ; 112(15): 4654-9, 2015 Apr 14.

Article em En | MEDLINE | ID: mdl-25775564

Assuntos

DNA/química; DNA/metabolismo; Conformação de Ácido Nucleico; Fatores de Transcrição/metabolismo; Algoritmos; Animais; Sequência de Bases; Sítios de Ligação/genética; Biologia Computacional/métodos; DNA/genética; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Cinética; Camundongos; Modelos Genéticos; Análise Serial de Proteínas; Ligação Proteica; Fatores de Transcrição/genética

Palavras-chave

DNA structure; protein binding microarray; protein−DNA recognition; statistical machine learning; support vector regression

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / DNA / Conformação de Ácido Nucleico Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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