Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun.
Org Biomol Chem
; 13(19): 5385-90, 2015 May 21.
Article
em En
| MEDLINE
| ID: mdl-25778494
ABSTRACT
We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
DNA
/
Proteínas Proto-Oncogênicas c-jun
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article