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Continuous theta burst stimulation over the left dorsolateral prefrontal cortex decreases medium load working memory performance in healthy humans.
Schicktanz, Nathalie; Fastenrath, Matthias; Milnik, Annette; Spalek, Klara; Auschra, Bianca; Nyffeler, Thomas; Papassotiropoulos, Andreas; de Quervain, Dominique J-F; Schwegler, Kyrill.
Afiliação
  • Schicktanz N; University of Basel, Department of Psychology, Division of Cognitive Neuroscience, Basel, Switzerland; University of Basel, Psychiatric University Clinics, Basel, Switzerland.
  • Fastenrath M; University of Basel, Department of Psychology, Division of Cognitive Neuroscience, Basel, Switzerland.
  • Milnik A; University of Basel, Department of Psychology, Division of Molecular Neuroscience, Basel, Switzerland; University of Basel, Psychiatric University Clinics, Basel, Switzerland.
  • Spalek K; University of Basel, Department of Psychology, Division of Cognitive Neuroscience, Basel, Switzerland.
  • Auschra B; University of Basel, Department of Psychology, Division of Molecular Neuroscience, Basel, Switzerland.
  • Nyffeler T; Departments of Neurology and Clinical Research, Perception and Eye Movement Laboratory, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland; Center of Neurology and Neurorehabilitation, Luzerner Kantonsspital, Luzern, Switzerland.
  • Papassotiropoulos A; University of Basel, Department of Psychology, Division of Molecular Neuroscience, Basel, Switzerland; University of Basel, Department Biozentrum, Life Sciences Training Facility, Basel, Switzerland; University of Basel, Psychiatric University Clinics, Basel, Switzerland.
  • de Quervain DJ; University of Basel, Department of Psychology, Division of Cognitive Neuroscience, Basel, Switzerland; University of Basel, Department Biozentrum, Life Sciences Training Facility, Basel, Switzerland; University of Basel, Psychiatric University Clinics, Basel, Switzerland.
  • Schwegler K; University of Basel, Department of Psychology, Division of Cognitive Neuroscience, Basel, Switzerland; University of Basel, Psychiatric University Clinics, Basel, Switzerland.
PLoS One ; 10(3): e0120640, 2015.
Article em En | MEDLINE | ID: mdl-25781012
ABSTRACT
The dorsolateral prefrontal cortex (DLPFC) plays a key role in working memory. Evidence indicates that transcranial magnetic stimulation (TMS) over the DLPFC can interfere with working memory performance. Here we investigated for how long continuous theta-burst stimulation (cTBS) over the DLPFC decreases working memory performance and whether the effect of cTBS on performance depends on working memory load. Forty healthy young subjects received either cTBS over the left DLPFC or sham stimulation before performing a 2-, and 3-back working memory letter task. An additional 0-back condition served as a non-memory-related control, measuring general attention. cTBS over the left DLPFC significantly impaired 2-back working memory performance for about 15 min, whereas 3-back and 0-back performances were not significantly affected. Our results indicate that the effect of left DLPFC cTBS on working memory performance lasts for roughly 15 min and depends on working memory load.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ritmo Teta / Córtex Pré-Frontal / Memória de Curto Prazo Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ritmo Teta / Córtex Pré-Frontal / Memória de Curto Prazo Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article