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Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities.
Witschel, Matthias C; Rottmann, Matthias; Schwab, Anatol; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit; Seet, Michael; Tonazzi, Sandro; Schwertz, Geoffrey; Stelzer, Frank; Mietzner, Thomas; McNamara, Case; Thater, Frank; Freymond, Céline; Jaruwat, Aritsara; Pinthong, Chatchadaporn; Riangrungroj, Pinpunya; Oufir, Mouhssin; Hamburger, Matthias; Mäser, Pascal; Sanz-Alonso, Laura M; Charman, Susan; Wittlin, Sergio; Yuthavong, Yongyuth; Chaiyen, Pimchai; Diederich, François.
Afiliação
  • Witschel MC; †BASF SE, Carl-Bosch-Strasse 38, 67056 Ludwigshafen, Germany.
  • Rottmann M; ‡Swiss Tropical and Public Health Institute (Swiss TPH), Socinstrasse 57, 4051 Basel, Switzerland.
  • Schwab A; §Universität Basel, Petersplatz 1, 4003 Basel, Switzerland.
  • Leartsakulpanich U; ∥Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
  • Chitnumsub P; ⊥National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani 12120, Thailand.
  • Seet M; ⊥National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani 12120, Thailand.
  • Tonazzi S; ∥Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
  • Schwertz G; ∥Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
  • Stelzer F; ∥Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
  • Mietzner T; †BASF SE, Carl-Bosch-Strasse 38, 67056 Ludwigshafen, Germany.
  • McNamara C; †BASF SE, Carl-Bosch-Strasse 38, 67056 Ludwigshafen, Germany.
  • Thater F; #California Institute for Biomedical Research (Calibr), 11119 North Torrey Pines Road, Suite 100, La Jolla, California 92037, United States.
  • Freymond C; †BASF SE, Carl-Bosch-Strasse 38, 67056 Ludwigshafen, Germany.
  • Jaruwat A; ‡Swiss Tropical and Public Health Institute (Swiss TPH), Socinstrasse 57, 4051 Basel, Switzerland.
  • Pinthong C; §Universität Basel, Petersplatz 1, 4003 Basel, Switzerland.
  • Riangrungroj P; ⊥National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani 12120, Thailand.
  • Oufir M; ∞Department of Biochemistry and Center of Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, 272 Rama VI Road, Bangkok 10400, Thailand.
  • Hamburger M; ⊥National Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani 12120, Thailand.
  • Mäser P; ×Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
  • Sanz-Alonso LM; ×Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
  • Charman S; ‡Swiss Tropical and Public Health Institute (Swiss TPH), Socinstrasse 57, 4051 Basel, Switzerland.
  • Wittlin S; §Universität Basel, Petersplatz 1, 4003 Basel, Switzerland.
  • Yuthavong Y; ¶Diseases of the Developing World (DDW), GlaxoSmithKline, C. Severo Ochoa, 2, 28760 Tres Cantos, Spain.
  • Chaiyen P; ○Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, 381 Royal Parade, Parkville, Victoria 3052, Australia.
  • Diederich F; ‡Swiss Tropical and Public Health Institute (Swiss TPH), Socinstrasse 57, 4051 Basel, Switzerland.
J Med Chem ; 58(7): 3117-30, 2015 Apr 09.
Article em En | MEDLINE | ID: mdl-25785478
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Plasmodium vivax / Glicina Hidroximetiltransferase / Inibidores Enzimáticos / Antimaláricos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Plasmodium vivax / Glicina Hidroximetiltransferase / Inibidores Enzimáticos / Antimaláricos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article