Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.

Ma, Xiaotu; Edmonson, Michael; Yergeau, Donald; Muzny, Donna M; Hampton, Oliver A; Rusch, Michael; Song, Guangchun; Easton, John; Harvey, Richard C; Wheeler, David A; Ma, Jing; Doddapaneni, HarshaVardhan; Vadodaria, Bhavin; Wu, Gang; Nagahawatte, Panduka; Carroll, William L; Chen, I-Ming; Gastier-Foster, Julie M; Relling, Mary V; Smith, Malcolm A; Devidas, Meenakshi; Guidry Auvil, Jaime M; Downing, James R; Loh, Mignon L; Willman, Cheryl L; Gerhard, Daniela S; Mullighan, Charles G; Hunger, Stephen P; Zhang, Jinghui

Ma, Xiaotu; Edmonson, Michael; Yergeau, Donald; Muzny, Donna M; Hampton, Oliver A; Rusch, Michael; Song, Guangchun; Easton, John; Harvey, Richard C; Wheeler, David A; Ma, Jing; Doddapaneni, HarshaVardhan; Vadodaria, Bhavin; Wu, Gang; Nagahawatte, Panduka; Carroll, William L; Chen, I-Ming; Gastier-Foster, Julie M; Relling, Mary V; Smith, Malcolm A; Devidas, Meenakshi; Guidry Auvil, Jaime M; Downing, James R; Loh, Mignon L; Willman, Cheryl L; Gerhard, Daniela S; Mullighan, Charles G; Hunger, Stephen P; Zhang, Jinghui.

Afiliação

Ma X; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Edmonson M; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Yergeau D; Pediatric Cancer Genome Project Validation Lab, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Muzny DM; Cancer Genomics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Hampton OA; Cancer Genomics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Rusch M; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Song G; Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Easton J; Pediatric Cancer Genome Project Validation Lab, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Harvey RC; University of New Mexico Cancer Center, Albuquerque, New Mexico 87131, USA.
Wheeler DA; Cancer Genomics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Ma J; Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Doddapaneni H; Cancer Genomics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.
Vadodaria B; Pediatric Cancer Genome Project Validation Lab, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Wu G; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Nagahawatte P; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Carroll WL; Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016, USA.
Chen IM; University of New Mexico Cancer Center, Albuquerque, New Mexico 87131, USA.
Gastier-Foster JM; 1] Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio 43205, USA [2] Departments of Pathology and Pediatrics, The Ohio State University, Columbus, Ohio 43210, USA.
Relling MV; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Smith MA; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland 20892, USA.
Devidas M; Department of Biostatistics, Colleges of Medicine, Public Health &Health Professions, University of Florida, Gainesville, Florida 32607, USA.
Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Downing JR; Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Loh ML; Department of Pediatrics, Benioff Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA.
Willman CL; University of New Mexico Cancer Center, Albuquerque, New Mexico 87131, USA.
Gerhard DS; Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Mullighan CG; Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Hunger SP; Division of Oncology and The Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Zhang J; Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Nat Commun ; 6: 6604, 2015 Mar 19.

Article em En | MEDLINE | ID: mdl-25790293

Assuntos

Evolução Clonal/genética; Recidiva Local de Neoplasia/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras B/genética; 5'-Nucleotidase/genética; Proteína de Ligação a CREB/genética; Criança; Células Clonais; Variações do Número de Cópias de DNA; Progressão da Doença; Exoma; Proteínas da Matriz Extracelular/genética; Feminino; GTP Fosfo-Hidrolases/genética; Histona-Lisina N-Metiltransferase/genética; Humanos; Fator de Transcrição Ikaros/genética; Masculino; Proteínas de Membrana/genética; Mutação; Proteínas Repressoras/genética; Proteína Supressora de Tumor p53/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Evolução Clonal / Recidiva Local de Neoplasia Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Child / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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