Biological evaluation and molecular modelling study of thiosemicarbazide derivatives as bacterial type IIA topoisomerases inhibitors.

Paneth, Agata; Staczek, Pawel; Plech, Tomasz; Strzelczyk, Aleksandra; Dzitko, Katarzyna; Wujec, Monika; Kusmierz, Edyta; Kosikowska, Urszula; Grzegorczyk, Agnieszka; Paneth, Piotr

Paneth, Agata; Staczek, Pawel; Plech, Tomasz; Strzelczyk, Aleksandra; Dzitko, Katarzyna; Wujec, Monika; Kusmierz, Edyta; Kosikowska, Urszula; Grzegorczyk, Agnieszka; Paneth, Piotr.

Afiliação

Paneth A; a Department of Organic Chemistry , Medical University of Lublin , Poland .
Staczek P; e Institute of Applied Radiation Chemistry, Lodz University of Technology , Poland.
Plech T; b Department of Microbial Genetics and.
Strzelczyk A; a Department of Organic Chemistry , Medical University of Lublin , Poland .
Dzitko K; b Department of Microbial Genetics and.
Wujec M; c Department of Immunoparasitology , University of Lódz , Poland .
Kusmierz E; a Department of Organic Chemistry , Medical University of Lublin , Poland .
Kosikowska U; a Department of Organic Chemistry , Medical University of Lublin , Poland .
Grzegorczyk A; d Department of Pharmaceutical Microbiology , Medical University of Lublin , Poland , and.
Paneth P; d Department of Pharmaceutical Microbiology , Medical University of Lublin , Poland , and.

J Enzyme Inhib Med Chem ; 31(1): 14-22, 2016.

Article em En | MEDLINE | ID: mdl-25792505

Assuntos

Antibacterianos/farmacologia; DNA Girase/metabolismo; Enterococcus faecalis/enzimologia; Modelos Moleculares; Semicarbazidas/farmacologia; Staphylococcus aureus/enzimologia; Inibidores da Topoisomerase II/farmacologia; Animais; Antibacterianos/síntese química; Antibacterianos/química; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; DNA Topoisomerases Tipo II; Relação Dose-Resposta a Droga; Enterococcus faecalis/efeitos dos fármacos; Fibroblastos/efeitos dos fármacos; Células HeLa; Humanos; Camundongos; Testes de Sensibilidade Microbiana; Estrutura Molecular; Semicarbazidas/síntese química; Semicarbazidas/química; Staphylococcus aureus/efeitos dos fármacos; Relação Estrutura-Atividade; Inibidores da Topoisomerase II/síntese química; Inibidores da Topoisomerase II/química

Palavras-chave

Antibacterials; bacterial type IIA topoisomerases; molecular modelling; thiosemicarbazide derivatives; toxicity

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Semicarbazidas / Staphylococcus aureus / Modelos Moleculares / Enterococcus faecalis / DNA Girase / Inibidores da Topoisomerase II / Antibacterianos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google