Live donor liver transplantation: a valid alternative for critically ill patients suffering from acute liver failure.
Am J Transplant
; 15(6): 1591-7, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25799890
ABSTRACT
We report the outcome of live donor liver transplantation (LDLT) for patients suffering from acute liver failure (ALF). From 2006 to 2013, all patients with ALF who received a LDLT (n = 7) at our institution were compared to all ALF patients receiving a deceased donor liver transplantation (DDLT = 26). Groups were comparable regarding pretransplant ICU stay (DDLT 1 [0-7] vs. LDLT 1 days [0-10]; p = 0.38), mechanical ventilation support (DDLT 69% vs. LDLT 57%; p = 0.66), inotropic drug requirement (DDLT 27% vs. LDLT 43%; p = 0.64) and dialysis (DDLT 2 vs. LDLT 0 patients; p = 1). Median evaluation time for live donors was 24 h (18-72 h). LDLT versus DDLT had similar incidence of overall postoperative complications (31% vs. 43%; p = 0.66). No difference was detected between LDLT and DDLT patients regarding 1- (DDLT 92% vs. LDLT 86%), 3- (DDLT 92% vs. LDLT 86%), and 5- (DDLT 92% vs. LDLT 86%) year graft and patient survival (p = 0.63). No severe donor complication (Dindo-Clavien ≥3 b) occurred after live liver donation. ALF is a severe disease with high mortality on liver transplant waiting lists worldwide. Therefore, LDLT is an attractive option since live donor work-up can be expedited and liver transplantation can be performed within 24 h with excellent short- and long-term outcomes.
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Base de dados:
MEDLINE
Assunto principal:
Doadores de Tecidos
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Transplante de Fígado
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Estado Terminal
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Falência Hepática Aguda
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Doadores Vivos
Tipo de estudo:
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article