Epigenetic modifications and long noncoding RNAs influence pancreas development and function.
Trends Genet
; 31(6): 290-9, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25812926
ABSTRACT
Insulin-producing ß cells within the pancreatic islet of Langerhans are responsible for maintaining glucose homeostasis; the loss or malfunction of ß cells results in diabetes mellitus. Recent advances in cell purification strategies and sequencing technologies as well as novel molecular tools have revealed that epigenetic modifications and long noncoding RNAs (lncRNAs) represent an integral part of the transcriptional mechanisms regulating pancreas development and ß cell function. Importantly, these findings have uncovered a new layer of gene regulation in the pancreas that can be exploited to enhance the restoration and/or repair of ß cells to treat diabetes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ilhotas Pancreáticas
/
Regulação da Expressão Gênica no Desenvolvimento
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Epigênese Genética
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RNA Longo não Codificante
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article