Is the sinusoidal obstructive syndrome post-liver transplantation a pathologic entity with a multifactorial etiology?
Rev Esp Enferm Dig
; 107(4): 235-8, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25824926
ABSTRACT
The sinusoidal obstructive syndrome is a complication typically associated with hematopoietic stem cell transplantation. This syndrome, more commonly known as veno-occlusive disease, has also been described after liver transplantation. It can have a life-threatening course. Herein, we describe the hepatic graft loss secondary to the development of a sinusoidal obstructive syndrome after a severe acute cellular rejection and toxic levels of once daily modified released tacrolimus (TAC). We discuss the role of the endotheliitis of acute rejection and toxic metabolites of some immunosuppressants such as azathioprine and TAC. Based on the current scientific evidence, we contemplate the possibility that the etiology of sinusoidal obstruction syndrome post-liver transplantation is multifactorial.
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Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Hepatopatia Veno-Oclusiva
/
Transplante de Fígado
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article