Adipose-derived stem cells for nerve repair: hype or reality?
Cells Tissues Organs
; 200(1): 23-30, 2014.
Article
em En
| MEDLINE
| ID: mdl-25825218
ABSTRACT
Peripheral nerve injury is a relatively commonly occurring trauma which seriously compromises the quality of life for many individuals. There is a major need to devise new treatment strategies, and one possible approach is to develop cellular therapies to bioengineer new nerve tissue and/or modulate the endogenous regenerative mechanisms within the peripheral nervous system. In this short review we describe how stem cells isolated from adipose tissue could be a suitable element of this approach. We describe the possible mechanisms through which the stem cells might exert a positive influence on peripheral nerve regeneration. These include their ability to differentiate into cells resembling Schwann cells and their secretion of a plethora of neurotrophic growth factors. We also review the literature describing the effects of these cells when tested using in vivo peripheral nerve injury models.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nervos Periféricos
/
Células-Tronco
/
Tecido Adiposo
/
Regeneração Nervosa
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article