See-through Brains and Diffusion Tensor MRI Clarified Fiber Connections: A Preliminary Microstructural Study in a Mouse with Callosal Agenesis.
Magn Reson Med Sci
; 14(2): 159-62, 2015.
Article
em En
| MEDLINE
| ID: mdl-25833270
ABSTRACT
Clearing methods that render the brain optically transparent allow high-resolution three-dimensional (3D) imaging of neural networks. We used diffusion tensor imaging (DTI) and two-photon imaging of cleared brains to analyze white matter in BTBR mice. We confirmed corpus callosum agenesis and identified an abnormal commissure close to the third ventricle. DTI and cleared-brain two-photon imaging revealed that these commissural fibers constituted a frontal clustering of the ventral hippocampal commissure and provided a detailed assessment of white matter structure in mice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Imagem de Difusão por Ressonância Magnética
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Imagem de Tensor de Difusão
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Agenesia do Corpo Caloso
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article