Characterization of G protein coupling mediated by the conserved D134(3.49) of DRY motif, M241(6.34), and F251(6.44) residues on human CXCR1.

Han, Xinbing; Feng, Yan; Chen, Xinhua; Gerard, Craig; Boisvert, William A

Han, Xinbing; Feng, Yan; Chen, Xinhua; Gerard, Craig; Boisvert, William A.

Afiliação

Han X; Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.
Feng Y; First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830054, China.
Chen X; Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, United States.
Gerard C; Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, United States.
Boisvert WA; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, United States ; Kazan Federal University, Kazan, Russia.

FEBS Open Bio ; 5: 182-90, 2015.

Article em En | MEDLINE | ID: mdl-25834784

Palavras-chave

CXCR1; CXCR1, CXC receptor 1; Chemokine receptor; Constitutive activity; DRY motif, Asp-Arg-Tyr motif; G protein coupled receptor; GPCR, G protein-coupled receptor; Gα15; Gαi; IL-8, interleukin 8; IP, inositol phosphate; Kd, affinity constants; PLC, phospholipase C; PTX, pertussis toxin; TMs, transmembrane domain; WT, wild type; i2, intracellular loop 2; i3, intracellular loop 3

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article