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Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness.
Katajisto, Pekka; Döhla, Julia; Chaffer, Christine L; Pentinmikko, Nalle; Marjanovic, Nemanja; Iqbal, Sharif; Zoncu, Roberto; Chen, Walter; Weinberg, Robert A; Sabatini, David M.
Afiliação
  • Katajisto P; Whitehead Institute for Biomedical Research, Boston, MA 02142, USA. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA. Institute of Biotechnology, University of Helsinki, P.O. Box 00014, Helsin
  • Döhla J; Institute of Biotechnology, University of Helsinki, P.O. Box 00014, Helsinki, Finland.
  • Chaffer CL; Whitehead Institute for Biomedical Research, Boston, MA 02142, USA.
  • Pentinmikko N; Institute of Biotechnology, University of Helsinki, P.O. Box 00014, Helsinki, Finland.
  • Marjanovic N; Whitehead Institute for Biomedical Research, Boston, MA 02142, USA. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  • Iqbal S; Institute of Biotechnology, University of Helsinki, P.O. Box 00014, Helsinki, Finland.
  • Zoncu R; Whitehead Institute for Biomedical Research, Boston, MA 02142, USA. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.
  • Chen W; Whitehead Institute for Biomedical Research, Boston, MA 02142, USA. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA.
  • Weinberg RA; Whitehead Institute for Biomedical Research, Boston, MA 02142, USA. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
  • Sabatini DM; Whitehead Institute for Biomedical Research, Boston, MA 02142, USA. Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA. Broad Institute, Cambridge, MA 02142, USA. The David H. Koch Institute for
Science ; 348(6232): 340-3, 2015 Apr 17.
Article em En | MEDLINE | ID: mdl-25837514
ABSTRACT
By dividing asymmetrically, stem cells can generate two daughter cells with distinct fates. However, evidence is limited in mammalian systems for the selective apportioning of subcellular contents between daughters. We followed the fates of old and young organelles during the division of human mammary stemlike cells and found that such cells apportion aged mitochondria asymmetrically between daughter cells. Daughter cells that received fewer old mitochondria maintained stem cell traits. Inhibition of mitochondrial fission disrupted both the age-dependent subcellular localization and segregation of mitochondria and caused loss of stem cell properties in the progeny cells. Hence, mechanisms exist for mammalian stemlike cells to asymmetrically sort aged and young mitochondria, and these are important for maintaining stemness properties.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Divisão Celular / Senescência Celular / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Divisão Celular / Senescência Celular / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article