Phospholipase A2 receptor and sarcoidosis-associated membranous nephropathy.
Nephrol Dial Transplant
; 30(6): 1047-50, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25839741
ABSTRACT
Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with active sarcoidosis. Our results suggest some causal link between sarcoidosis and PLA2R-related MN. Detection of anti-PLA2R antibodies in serum or PLA2R antigen in biopsy should not be taken as evidence against a secondary cause, particularly sarcoidosis. This important observation can affect treatment decision in these patients.
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Base de dados:
MEDLINE
Assunto principal:
Sarcoidose
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Glomerulonefrite Membranosa
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Anticorpos Anti-Idiotípicos
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Receptores da Fosfolipase A2
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article