Antinociceptive, anti-inflammatory and smooth muscle relaxant activities of the pyrrolo[3,4-d]pyridazinone derivatives: Possible mechanisms of action.

Mogilski, Szczepan; Kubacka, Monika; Redzicka, Aleksandra; Kazek, Grzegorz; Dudek, Magdalena; Malinka, Wieslaw; Filipek, Barbara

Mogilski, Szczepan; Kubacka, Monika; Redzicka, Aleksandra; Kazek, Grzegorz; Dudek, Magdalena; Malinka, Wieslaw; Filipek, Barbara.

Afiliação

Mogilski S; Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland. Electronic address: szczepan.mogilski@uj.edu.pl.
Kubacka M; Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
Redzicka A; Department of Chemistry of Drugs, Wroclaw Medical University, 211 Borowska Str., 50-556 Wroclaw, Poland.
Kazek G; Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
Dudek M; Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
Malinka W; Department of Chemistry of Drugs, Wroclaw Medical University, 211 Borowska Str., 50-556 Wroclaw, Poland.
Filipek B; Department of Pharmacodynamics, Faculty of Pharmacy, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.

Pharmacol Biochem Behav ; 133: 99-110, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25847619

Assuntos

Analgésicos/farmacologia; Anti-Inflamatórios não Esteroides/farmacologia; Relaxamento Muscular/efeitos dos fármacos; Músculo Liso/efeitos dos fármacos; Piridazinas/farmacologia; Pirróis/farmacologia; Animais; Células Cultivadas; Cobaias; Antagonistas dos Receptores Histamínicos H1/farmacologia; Masculino; Camundongos; Estrutura Molecular; Medição da Dor/efeitos dos fármacos; Piridazinas/química; Pirróis/química; Ratos; Teste de Desempenho do Rota-Rod

Palavras-chave

Histamine; Inflammation; Pain; Pyridazinone; Smooth muscle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridazinas / Pirróis / Anti-Inflamatórios não Esteroides / Analgésicos / Relaxamento Muscular / Músculo Liso Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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