Linking microtubules to Parkinson's disease: the case of parkin.
Biochem Soc Trans
; 43(2): 292-6, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25849932
Microtubules (MTs) are dynamic polymers consisting of α/ß tubulin dimers and playing a plethora of roles in eukaryotic cells. Looking at neurons, they are key determinants of neuronal polarity, axonal transport and synaptic plasticity. The concept that MT dysfunction can participate in, and perhaps lead to, Parkinson's disease (PD) progression has been suggested by studies using toxin-based and genetic experimental models of the disease. Here, we first learn lessons from MPTP and rotenone as well as from the PD related genes, including SNCA and LRRK2, and then look at old and new evidence regarding the interplay between parkin and MTs. Data from experimental models and human cells point out that parkin regulates MT stability and strengthen the link between MTs and PD paving the way to a viable strategy for the management of the disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson Secundária
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Ubiquitina-Proteína Ligases
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Microtúbulos
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Neurônios
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article